Jagged Little Pill is began performances on May 5, 2018, at the Loeb Drama Center, within the American Repertory Theater in Cambridge, Massachusetts, for a limited run to July 15, 2018. Notable casting for the show included Elizabeth Stanley as Mary Jane, Derek Klena as Nick, Lauren Patten as Jo, Sean Allan Krill as Steve and Celia Gooding as Frankie. The show has a book by Diablo Cody, with direction by Diane Paulus, choreography by Sidi Larbi Cherkaou, set design by Riccardo Hernandez, costume design by Emily Rebholz, lighting design by Justin Townsend, and video design by Finn Ross. Music and lyrics are by Alanis Morissette & Glen Ballard, with musical direction by Bryan Perri, sound design by Jonathan Deans and orchestration by Tom Kitt.
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