Resident Evil is an action-horror film series loosely based on the Japanese video game franchise of the same name by Capcom. German studio Constantin Film bought the rights to the first film in January 1997 with Alan B. McElroy and George A. Romero as potential writers. In 2001, Sony Pictures Entertainment acquired distribution rights and hired Paul W. S. Anderson as writer and director for Resident Evil (2002). Anderson continued as writer and producer for Resident Evil: Apocalypse (2004) and Resident Evil: Extinction (2007), and returned as the director for Resident Evil: Afterlife (2010), Resident Evil: Retribution (2012) and Resident Evil: The Final Chapter (2016).

Resident Evil

Underneath Raccoon City exists a genetic research facility called the Hive, owned by the Umbrella Corporation. A thief steals the genetically engineered T-virus and contaminates the Hive with it. In response, the facility’s artificial intelligence, the Red Queen, seals the Hive and kills everyone inside.

Alice awakens naked in the bathroom of a deserted mansion with amnesia. She dresses, checks the mansion, and is subdued by an unknown person. A group of Sanitation Team commandos led by James Shade breaks into the mansion and arrests Matt Addison, who just transferred as a cop in Raccoon P.D. The group travels to the underground train under the mansion that leads to the Hive, where they find Spence. The commandos explain that everyone in the group except Matt is an employee of the Umbrella Corporation, and Alice and her partner Spence are security guards for a Hive entrance under the disguise of a couple living in the mansion. Five hours prior, the Red Queen had shut down the entire facility and killed everyone inside, and also caused Spence and Alice’s amnesia by flooding the mansion with nerve gas.

At the Queen’s chamber, a laser defense system kills Shade and three more commandos. Despite the Red Queen’s urgent pleas for the group to leave, Kaplan disables the Red Queen systems, and the power fails, opening all of the doors in the Hive. This releases the zombified staff and containment units containing Lickers, creatures created through experimentation with the T-virus. When everyone regroups, they are ambushed by a horde of zombies and a gunfight ensues. J.D. perishes as the group becomes overwhelmed. A bitten Rain retreats with Kaplan and Spence; Matt becomes separated from Alice, who starts regaining her memories.

Matt looks for information about his sister Lisa and finds her zombified. Alice saves him, and Matt explains he and Lisa were environmental activists, and Lisa infiltrated Umbrella to smuggle out the evidence of illegal experiments. Alice re she was Lisa’s in the Hive but does not tell Matt. The survivors reunite at the Queen’s chamber, and the commandos explain they have one hour before the Hive traps them inside automatically. Alice and Kaplan activate the Red Queen to find an exit. To force her cooperation, they rig a remote shutdown. As they escape through maintenance tunnels, zombies ambush them, and a reanimated J.D. bites Rain before getting killed. The group reaches safety, but Kaplan is bitten and separated.

Alice re that an anti-virus is in the lab, but they find it missing. Spence re he stole and released the virus. He hid the T-virus and anti-virus on the train. Spence is bitten by a zombie, which he kills before trapping the survivors in the lab. He retrieves the anti-virus, but is ambushed and killed by a Licker. The Red Queen offers to spare Alice and Matt if they kill Rain, whose health is fading and who has been infected too long for the anti-virus to work reliably. As the Licker attempts to reach them, a power outage occurs. The lab door opens to reveal Kaplan forced the Red Queen to open the door. The group heads to the train, where Alice retrieves the T-virus and kills a reanimated Spence before escaping with the others.

On the train, they inject Rain and Kaplan with the anti-virus. However, the Licker is hiding on the train and attacks them, clawing Matt and killing Kaplan. In the ensuing battle, Alice subdues the Licker before Matt is attacked by a now-zombified Rain. He shoots Rain dead, causing her head to hit a trapdoor button, opening it and dropping the Licker under the train which ultimately kills it for good. At the mansion, Matt’s wound begins mutating. Before Alice can give him the anti-virus, the mansion doors burst open and a group of Umbrella scientists seizes them. They subdue Alice and take Matt away, revealing he is to be put into the Nemesis Program.

Some time later, Alice awakens at the Raccoon City Hospital strapped to an examination table, with no memory of what happened since her capture. After escaping, she goes outside to find Raccoon City abandoned and ruined. Alice arms herself with a shotgun from an abandoned police car as the camera pans out.

Resident Evil: Apocalypse

In the previous film, former security operative Alice and environmental activist Matt Addison fought to escape an underground genetic research facility called the Hive, the source of a zombie outbreak. The pair were part of an attempt to expose illegal experiments being performed there by pharmaceutical company Umbrella Corporation. The film ended as Alice and Addison were taken into custody by Umbrella.

Umbrella sends a team to the Hive to investigate what happened there; the team is overrun by zombies who quickly spread to the nearby Raccoon City. Umbrella responds by quarantining the city and evacuating their personnel from it. Angela Ashford, the daughter of Umbrella researcher Dr. Charles Ashford, goes missing after her security car is involved in a collision. Alice awakens in a deserted hospital and wanders the city in search of supplies, while Umbrella uses the only bridge out of the area to evacuate civilians. At the bridge, disgraced police officer Jill Valentine meets with her former partner, Sgt. Payton Wells. A zombie bites and infects Wells. In response to the virus reaching the bridge, Major Timothy Cain, leader of the Umbrella forces in Raccoon City, seals the exit and forces the residents to return to the city.

After being abandoned by their employer following a failed attempt to rescue a civilian, Umbrella soldiers Carlos Oliveira and Nicholai Ginovaef team up with the Raccoon City Police Special Tactics And Rescue Squad (STARS) to repel zombie attacks. Their position is overrun, and Oliveira is bitten and infected. At a separate location, Valentine, Wells, and news reporter Terri Morales, are about to be overrun, though they are saved by Alice. Umbrella deploys a heavily mutated experimental supersoldier, Nemesis, who kills the remaining STARS before searching for Alice. Dr. Ashford hacks into the city’s CCTV system and uses it to Alice and the other survivors, offering to arrange their evacuation from the city in exchange for help in locating his daughter. He makes an identical offer to Olivera and Ginovaef, and explains that Umbrella intends to rid Raccoon City of the zombie infection by destroying it using a nuclear bomb.

Alice and the others head to Angela’s location, where they are ambushed by Nemesis. Valentine kills Wells after he turns into a zombie. Alice engages Nemesis but is wounded and forced to retreat separately, luring Nemesis away from the rest of the group. Valentine and Morales continue, picking up stranded civilian L.J. en route. Valentine meets Olivera and they find and rescue Angela, although Morales and Ginovaef are both killed. Angela reveals that the zombie outbreak is the result of a virus created by her father to treat the genetic disease from which she suffers: only by regularly injecting herself with the virus is Angela able to survive, though she must also take anti-virus serum to prevent turning into a zombie. Alice uses some of the anti-virus to cure Olivera. Dr. Ashford gives Alice the location of an extraction point where a helicopter awaits. The group makes it to the rendezvous point, but are ambushed by Umbrella forces. Major Cain kills Dr. Ashford and forces Alice to fight Nemesis. Alice gains the upper hand over the supersoldier, though she ceases fighting after realizing that he is Matt Addison, mutated by Umbrella’s experiments.

Nemesis turns on Major Cain and attacks the Umbrella troops, but is killed protecting Alice. The rest of the survivors seize the helicopter; they eject Major Cain from it and he is eaten by zombies, including a zombified Dr. Ashford. As the survivors escape, the nuclear bomb detonates over the city, and the resulting blast wave causes the helicopter to crash. Alice sacrifices herself to save Angela and is impaled on a metal pole. TV footage attributes the nuclear attack to a meltdown of the city’s power plant, covering up Umbrella’s involvement. Alice wakes up in an Umbrella research facility and escapes with help from Olivera, Valentine, L.J., and Angela. As they are escaping, Dr. Alexander Isaacs, a high-ranking Umbrella employee, reveals that Alice’s escape is part of Umbrella’s plan for her.

Resident Evil: Extinction

Alice (Milla Jovovich) wakes up disoriented in a mansion. Wandering through its halls, she is forced to escape several security traps. However, she is eventually killed by a bounding mine hidden in the floor. Her body is dumped into a pit filled with dozens of Alice copies and is revealed to be one of many clones being produced inside of an underground facility whose entrance above ground is surrounded by thousands of zombies.

Despite the best efforts of the bio-tech company Umbrella Corporation to cover up the contamination of The Hive and the release of the T-virus to the surface, going so far as to authorize the bombing of Raccoon City, the T-virus has spread around the world. As the virus spread, it affected not only humans, but other animals as well, and the environment deteriorated, turning cities into desolate landscapes and the wilderness into wastelands. The real Alice (from whom the clones are made) wanders the wastelands of the Southwestern U.S. On her travels, she finds a dead man’s diary which states that there is an uninfected area in Alaska. She later begins to realize that she has developed telekinetic abilities due to the experiments performed on her.

Meanwhile, Dr. Alexander Isaacs (Iain Glen), former head of Project Alice and the head of the North American Umbrella facility seen earlier (based in Nevada), considers Alice’s recapture to be a top priority, since she has the ability to bond with the T-virus and not suffer mutation. He tries to persuade the Umbrella board, operating via holograms from the worldwide Umbrella facility, that he can use her blood to develop a permanent cure as well as tame the infected zombies. The new Umbrella chairman Albert Wesker (Jason O’Mara) orders Isaacs to use the clones to create a cure, and he refuses to authorize Alice’s recapture until they are informed of her location.

Meanwhile, a convoy of survivors led by Claire Redfield (Ali Larter) travels across the country in search of supplies. The convoy includes Raccoon City survivors Carlos Oliveira (Oded Fehr) and L.J. (Mike Epps), along with new survivors K-Mart (Spencer Locke), Mikey (Christopher Egan), Chase (Linden Ashby), Otto (Joe Hursley) and Nurse Betty (Ashanti Douglas), among others.

While searching a motel for supplies, L.J. is bitten by a zombie, which he keeps secret. The next morning the convoy is attacked by crows that had been feeding on the infected. The crows almost overwhelm the convoy, killing Nurse Betty and Otto and taking out the flamethrower operator, causing the weapon to careen out of control. Alice finally appears and saves Carlos and the others from a fiery death, using her telekinesis to fill the sky with fire, killing the crows and leaving her unconscious. After recovering, Alice is introduced to Claire and gives her the diary she found, and she and Carlos then convince Claire to take her convoy to Alaska.

Dr. Isaacs’ attempts to domesticate the infected have led to a new zombie breed that re basic things, such as how to use phones and cameras. Wesker’s security officer, Captain Alexander Slater (Matthew Marsden), is adamant about Isaacs’ disregard for Umbrella’s regulations. Wesker, in private, informs Slater to keep watch on Isaacs’ actions, and tells Slater that if Issacs disobeys orders, Slater should kill Isaacs.

Umbrella triangulates Alice’s location based on the signal sent out by her telekinetic abilities. Dr. Isaacs has a crate of his new zombies sent to ambush the convoy, against Wesker’s specific orders. L.J. succumbs to his infection and bites Carlos. Most of the convoy, including Mikey and Chase, are killed in the ambush. Umbrella tries to shut Alice down remotely, but she breaks free from their programming and continues to fight. She finds Isaacs at the scene, and he becomes infected as he flees via helicopter. Alice and K-Mart use Isaacs’ computer to track the helicopter’s flight path, leading them to Umbrella’s underground location.

The convoy heads over to the site, which is surrounded by thousands of zombies. Carlos sacrifices himself by plowing his truck into the zombie mob and blowing the rig apart, giving Alice and Claire time to load survivors into the helicopter. Alice decides to stay behind. Ordered by Wesker to terminate Isaacs, Slater arrives with a group of commandos and finds the scientist locked in his lab, injecting himself with massive doses of anti-virus in an attempt to counteract the infection. Slater reveals that his employment is terminated and shoots him, triggering a mutation that transforms Isaacs into a monstrous creature. Despite retaining his intelligence and thought, Isaacs kills Slater and all the facility employees, but is confined to the lab’s lower levels.

Entering the facility, Alice meets a holograph of the Red Queen’s “sister” AI, the White Queen (Madeline Carroll). The White Queen informs Alice that her blood is the cure to the T-virus, while also defending the Red Queen’s prior actions. She then tells Alice about Dr. Isaacs. Alice agrees to deal with him. On her way to the lab’s lower levels, Alice discovers one of her clones, still in development. The clone awakens, but appears to die from shock shortly after. Alice soon discovers a replica of the Racoon City mansion deep within the complex and finds Isaacs. The two engage in a fight, eventually leading them to a replica of The Hive’s laser corridor, where Isaacs is killed by the laser-defense system. Just as Alice is about to meet the same fate, the system is deactivated by her clone, whom is revealed to still be alive.

Later, in Tokyo, Japan, Wesker, who is the head of the Tokyo Umbrella facility, informs the rest of the Umbrella chairmen (all holograms) that the North American facility has been lost. Alice’s hologram makes an appearance, declaring that she is coming for him, and she’s bringing some of her “friends.” Standing beside her clone, Alice looks out onto a huge number of pods containing numerous developing clones.

Resident Evil: Afterlife

One year after the events of Extinction, Alice (Milla Jovovich) and her clones lead the assault to attack Umbrella HQ, located in Tokyo, slaying the entire branch except for Albert Wesker (Shawn Roberts), who escapes in a tiltrotor plane and detonates a bomb that leaves a massive sinkhole. The real Alice boarded beforehand and attempts to execute Wesker, only for him to inject her with an anti-virus to remove her superhuman abilities. Wesker is revealed to have used the T-Virus to gain his own superhuman abilities and prepares to kill Alice, before the autopilot crashes the plane into the mountains and only Alice survives.

Six months later, Alice travels to Alaska in an airplane, tracking broadcasts from a safe haven called Arcadia; however, she only finds abandoned planes, and is attacked by feral Claire Redfield (Ali Larter). Alice destroys a spider-like device on Claire’s chest, giving her amnesia and pacifying her. They travel to the ruins of Los Angeles, where they find survivors living in a prison which is surrounded by thousands of undead. They meet Luther West, (Boris Kodjoe) who leads the surviving band from the prison, Wendell (Fulvio Cecere), Crystal Waters (Kacey Clarke), Bennett (Kim Coates), Kim Yong (Norman Yeung), and Angel Ortiz (Sergio Peris-Mencheta). With their help, Alice finally lands on the prison’s roof and learns Arcadia isn’t a fixed place, but a cargo tanker traveling along the coast. However, though the ship hasn’t moved, no one from it has responded to the group’s rescue flares. Luther takes Alice to the last inmate, Chris (Wentworth Miller), who insists he’s falsely imprisoned, and will reveal an escape route in exchange for freedom. Alice goes to the showers to wash up, but catches Wendell attempting to peep. Holding him at gunpoint, they are attacked by a group of infected people that dug into the prison. They take Wendell, but she manages to kill them.

Desperate, they free Chris, who reveals that Claire is his sister, and the prison has an armored car they can use to escape. However, a giant axe-wielding monster begins breaking down the gate. Alice, Chris and Crystal go to the basement armory to get more guns; however, zombies kill Crystal en route. Luther and Claire reinforce the gate. Angel informs Bennett and Yong the car is missing its engine, and it would take a week to fix. Bennett shoots Angel and heads for Arcadia in Alice’s airplane. The Axeman breaks down the gate, allowing the zombies into the prison. The group decides to use the zombie-dug tunnels to escape into the sewers. Kim Yong is slashed in half by the Axeman, while Alice is knocked out. Claire successfully defends Alice, manages to defeat the Axeman and disorienting it, after which Alice kills it by firing at its head. Unfortunately, Luther is dragged back into the tunnels by a zombie.

Alice and the Redfields board the Arcadia, discovering it functional but abandoned. Claire then re Arcadia is an Umbrella trap to get test subjects; they release the survivors, among them K-Mart (Spencer Locke). Alice follows a trail of blood deeper into the ship, where she finds Wesker. The T-Virus revived him, but it battles Wesker for control, something he believes fresh human DNA can pacify; the Umbrella staff fled when he began eating test subjects. Alice’s DNA is superior to his, since she retained control despite her bonding with the virus at a cellular level. Wesker believes eating her will help him regain control of his body over the effects of the T-Virus.

The Redfields fight Wesker while Alice battles Bennett, now working for Wesker. Wesker easily overpowers Chris and Claire, but Alice is able to defeat both Bennett and Wesker with help from K-Mart. They lock Bennett in the room with Wesker’s corpse. Bennett is devoured by Wesker when he revives. Wesker then escapes in an aircraft, activating a bomb on the Arcadia; the plane explodes instead as Alice placed the bomb there beforehand. Unbeknownst to them, Wesker parachutes away from the explosion, while Luther emerges from the sewers, battered but alive. Alice resolves to turn Arcadia into a real haven and broadcasts a new message for any other survivors. As Alice, Claire and Chris watch over from Arcadia, it is approached by a military squadron of Umbrella aircraft.

During a mid-credits scene in one of the aircraft, Jill Valentine (Sienna Guillory), who went missing after the Raccoon City destruction incident, is dictating the attack wearing the same mind control device used on Claire.

Resident Evil: Retribution

Alice and the others on the Umbrella Corporation freighter Arcadia, now face an attack by an assaulting fleet of tiltrotor V-22 Ospreys led by Alice's former ally, Jill Valentine, resulting in the killing of many of the survivors in the ship. Alice is captured during the attack while the fates of Chris Redfield, Claire Redfield and K-Mart are left ambiguous.

The story switches to a suburban Alice living with her husband, Todd, and her deaf daughter Becky. Zombies attack, revealing the suburbia was actually Raccoon City during the contamination incident. Alice and Becky manage to run away from the undead, with the help of Rain Ocampo, by letting them ride in her car. As the three escape, they are hit by a garbage truck, knocking Rain unconscious. Alice hides Becky, but is killed by a zombified Todd.

Meanwhile, the real Alice awakens in an underground facility and is interrogated by Jill. During a power failure, Alice escapes her cell and the laser grid, finding herself in a simulation of Shibuya Square, Tokyo. Fighting her way out against zombies, she enters a control room filled with dead Umbrella employees and encounters Ada Wong, one of Albert Wesker's top agents. Wesker appears on a screen, explaining that they no longer serve Umbrella and the power outage was staged by Wesker's hacking into the facility's computer mainframe. Wesker also reveals that the Red Queen, one of Alice's arch-enemies, was reactivated after the Hive incident and now controls Umbrella. He furthermore explains that the facility is underwater, located in Kamchatka, Russia, and that it formerly served as a Soviet naval outpost.

The facility was designed by Umbrella for manufacturing clones and creating simulated outbreaks to show the effect of the T-virus. Ada and Alice plan to rendezvous with a rescue crew organized by Wesker, which includes Leon Kennedy, Barry Burton, and Luther West (Alice's former ally, who survived after the outbreak in Los Angeles). Leon's team plants explosives near the entrance of the facility, which will detonate in two hours to ensure the facility's destruction. The group plans to meet with Alice and Ada in the Raccoon City suburbia area. In a New York City simulation, Alice and Ada defeat two Executioners. Leon and his team enter a Moscow simulation (Red Square in front of the GUM façade), but they are cut off by a heavily armed Las Plagas undead horde, which has surrounded them.

In the Suburban setting, Alice and Ada encounter Becky, who mistakes Alice for her clone mother, and is instantly attached to her. They also encounter the clones, which consists of Alice's deceased allies; James "One" Shade, "evil" Rain Ocampo and Carlos Olivera, who are sent to capture them. During the shootout which was triggered by Ada, she gives Alice her smart glasses and her grappling hook so that she and Becky can find their way out, and they become separated. They encounter the "good" clone of Rain (who they met in Suburbia at the beginning) in the Moscow simulation (Arbatskaya metro station), and Alice gives her a weapon. She then rescues Leon's surviving crew from the barrage of Las Plagas zombies and a giant Licker. Once united, the group heads toward the tunnel and reaches the submarine pens in the facility exit, but they are ambushed by Jill's team. Becky is captured by the Licker, and "good" Rain is killed, breaking her neck after being thrown by the Licker. Alice rescues Becky, and also kills the Licker using a belt of grenades she found. Barry sacrifices himself in the process, holding the Umbrella operatives off long enough to ensure the others' escape. Using Leon's bombs, they finally manage to destroy the facility, allowing Leon and Luther to escape, while Alice and Becky also survive, having used the ventilation system.

On the surface, their snowmobile is knocked over by Jill Valentine's Oscar-Class submarine. Jill and "bad" Rain confront the group with Ada being held as their hostage. Jill and Alice begin fighting each other, while Rain - now also enhanced with the Las Plagas parasite, granting her superhuman strength and healing - fights Leon and Luther. Alice is able to tear the mind-controlling scarab off Jill's chest, returning her to her normal self. Unfortunately, Rain also kills Luther in the process, while Leon is knocked out. Realizing that they can't kill Rain, Alice shoots the ice under her feet and she is dragged down by the swimming zombies from the undersea installation to be devoured, killing her for good. Alice, Ada, Becky, Leon, and Jill travel to Wesker's headquarters, a heavily barricaded and fortified White House, staffed by the remainders of the U.S. Armed Forces. Alice meets Wesker in the heavily barricaded Oval Office, where he injects her with the T-virus, returning her superhuman abilities; as only Alice successfully bonded with it, she is the ultimate weapon. On the roof, Wesker explains that the Red Queen is trying to wipe out humanity, and all of the remaining uninfected humans are in the base; it is humanity's last stand. A pull-away shows the U.S. Military defending the White House alongside the remaining Umbrella Corp. soldiers against enormous hordes of T-virus abominations swarming all over the walls.

Resident Evil: The Final Chapter

Dr. James Marcus, the original founder of the Umbrella Corporation, had a daughter who was dying of premature aging. Desperate to save her, Marcus discovered the T-virus. Unfortunately, the virus had the side effect of sudden and uncontrollable mutation; in Cape Town, South Africa, a boy dies in a cable car ascending to Table Mountain, then reanimates and kills the other engers. Marcus tried to have the program shut down, despite protests from his colleague Dr. Alexander Isaacs (Iain Glen). When Marcus refused, Isaacs ordered Albert Wesker to kill him. The Red Queen is then created using childhood images of Marcus' daughter.

Some time after the events of the previous film, Alice awakens in the now-ruined White House after being betrayed once again by Wesker. While she is searching for survivors, the Red Queen appears and tells Alice she must return to the Hive, over 400 miles west on I-64 in Raccoon City, within 48 hours. The Umbrella Corporation has developed an airborne antivirus, which can kill every organism infected by the T-virus (which may or may not include Alice), and is just waiting for the remaining few thousand humans to be wiped out. When asked why she is betraying her creators, the Red Queen says that she will explain once Alice arrives at the Hive.

On her way to Raccoon City, Alice is captured by Isaacs — learning the one she previously killed was just a clone — though she manages to escape his convoy. Alice later arrives in Raccoon City and is ambushed by a group of survivors, consisting of Doc, Abigail, Christian, Cobalt, Razor, and Alice's friend Claire Redfield, who survived the attack on Arcadia. With Isaacs' convoy approaching, trailed by a horde of zombies, the group prepares for battle. They defeat the convoy, retrieve Isaacs' few human captives and burn the horde, though Cobalt is killed. With more undead on the way and no defenses left, Alice and crew head for the Hive entrance, located at the bottom of the crater from the nuclear bomb dropped on the city. Wesker, having taken control of the Hive, releases mutated guard dogs, killing Christian and a freed captive.

Inside the Hive, the Red Queen appears to Alice and explains her reason for betraying Umbrella. She reveals that a video was ed to her program which contained the recording of Isaacs explaining to Umbrella's executives the plan to release the T-virus, cleansing the world of man-made catastrophes while saving the rich and powerful in cryogenic capsules hidden in the Hive, and later rebuild the world in their image. The Red Queen program is in conflict, as she can never hurt an Umbrella employee but also must value remaining human life, which is why she enlists Alice's help in order to stop Isaacs. Before proceeding onwards, Alice is silently warned by The Red Queen that someone in her group is a spy for Umbrella.

Navigating the Hive, the group encounter several traps, resulting in the deaths of Abigail and Razor along with the remaining freed captive. Alice and Doc plant bombs throughout the Hive taken from the leftover equipment of the original team to investigate the Hive. Alice confronts the real (tech-upgraded) Isaacs, whereupon she is held at gunpoint by Doc — Umbrella's spy — while Claire is captured by Wesker. A cryogenic capsule opens, releasing Alicia Marcus, Umbrella's co-leader and Marcus' daughter. Isaacs reveals to Alice that she is actually a clone of Alicia, before going on to explain his plan in eliminating the pair so that he can assume full control of Umbrella. Though Issacs is the co-founder of Umbrella, Alicia points out that Wesker is merely an employee and proceeds to "fire" him, allowing the Red Queen to crush his legs with a security door. Doc tries to shoot Alice, but he finds his gun empty — as Alice had earlier deduced his treachery — and Claire executes him. After giving Wesker the dean's switch to the bombs she planted, Alice and Claire pursue Isaacs while Alicia willingly stays behind to review her childhood memories with her father.

Upon catching up to Isaacs, Alice and Claire fight him as the trio are lifted back up to the Hive. Isaacs overpowers Claire and attacks Alice in the Laser Corridor. Alice manages to dodge the lasers before re-engaging Isaacs, eventually beating him when she secretly activates a grenade in his pocket. She escapes to the surface with the anti-virus, but Isaacs reboots and follows; he catches her just as she's about to release the antivirus. Before he can kill Alice, however, Isaacs is confronted and instantly killed by his clone, which Alice encountered en route to Raccoon City; the clone is then devoured by the undead. The distraction allows Alice to release the antivirus, killing all of the undead around her before she es out. Wesker simultaneously drops the dean's switch, destroying the Hive along with the hibernating Umbrella elite; Alicia and Wesker are killed in the process.

Claire wakes Alice, who survived because the antivirus killed only the T-virus within her body, not the healthy cells. The Red Queen gives Alice an of all of Alicia's memories, granting her a childhood. Alice travels into Manhattan, saying that the antivirus, carried only by the winds, will take years to reach all corners of the globe. Until then, says Alice, her mission is not finished.